Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

Figure 1

Schematic diagram of the ezrin protein domain. Ezrin protein has two functional domains connected through the α-helical domain: the N-terminal FERM (F for 4.1 protein, E for ezrin, R for radixin, and M for moesin, amino acid 1–296) domain and the C-terminal C-ERMAD (amino acid residues 470–586). The FERM domain comprises three subdomains (F1: a ubiquitin-like domain; F2: with four α-helices; and F3: a pleckstrin homology domain). C-ERMAD contains F-actin binding sites, which can bind to FERM domains or actin. The central helical (amino acid residues 297–469) domain comprises three α helices: α1H, α2H, and α3H, forming a coiled-coil in the monomer structure. Abbreviations: Thr: threonine; Tyr: tyrosine; Ser: serine; Arg: arginine; Glu: glutamic; PIP2: phosphatidylinositol 4,5-bisphosphate; NIK: Nck-interacting kinase; GRK2: G protein-coupled receptor kinase 2; CDK5: cyclin-dependent kinase 5; PI3K: phosphoinositide 3-kinase; Akt (PKB): protein kinase B; PKA: protein kinase A; EGF: epidermal growth factor.