Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

Figure 2

Role of ezrin in asthma-related airway inflammation. Abbreviations: ILC2: type 2 innate lymphoid cells; Th2: type 2 T-helper cells; P: phosphorylate; -P: dephosphorylate; JAK2: Janus Kinase 2; STAT6: signal transducers and activators of transcription 6; TSLP: thymic stromal lymphopoietin; FcεRI: Receptor I for the Fc Fragment of IgE; Pak1: kinase 1; PP2A: protein phosphatase 2A; T567: threonine 567; LPS: Lipopolysaccharide; TLR4: toll-like receptor 4; ROCK: Rho-associated coiled-coil containing protein kinase; MyD88: myeloid differentiation factor 88; IRAK-1: IL-1R-associated kinase 1; HRV: human rhinovirus; ICAM-1: intracellular adhesion molecules-1; Syk: spleen tyrosine kinase; PI3K: phosphoinositide 3-kinase; Akt (PKB): protein kinase B; NE: Neutrophil elastase; PIP2: phosphatidylinositol 4,5-bisphosphate; MUC5AC: robust mucin 5 AC; IL-25: interleukin-25; IL-4: interleukin-4; IL-13: interleukin-13; IL-8: interleukin-8; IL-1β: interleukin-1β; TNF-α: tumor necrosis factor-α.