Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

<div>Ezrin and epithelial integrity. Abbreviations: <i>β</i>2AR: <i>β</i>2 adrenergic receptor; NHERF1: <svg height="8.87491pt" id="M2" style="vertical-align:-0.3499308pt" version="1.1" viewbox="-0.0498162 -8.52498 53.9692 8.87491" width="53.9692pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M719 650H483V622C553 619 576 606 581 560C585 532 588 487 588 394V148H585L167 650H20V622C67 618 88 610 109 585C127 562 129 557 129 484V264C129 173 126 124 123 93C118 44 92 31 35 28V0H272V28C204 32 181 44 176 95C173 124 170 172 170 264V515H172L598 -9H629V394C629 487 631 532 635 563C639 606 663 619 719 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.32,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 365 44 353 44 339C44 315 69 296 87 296C101 296 111 303 116 319C124 349 133 371 145 385C156 397 171 404 190 404C241 404 275 364 275 291V274C253 256 180 229 120 209C65 190 39 159 39 110C39 47 88 -12 159 -12C189 -12 237 25 277 52C282 35 288 21 301 8C312 -3 333 -12 348 -12L433 39ZM275 84C256 65 221 48 195 48C164 48 124 73 124 124C124 161 146 180 185 198C206 208 254 229 275 240V84Z"></path></g><g transform="matrix(.013,0,0,-0.013,17.99,0)"><path d="M535 230V280H323V490H265V280H52V230H265V-3H323V230H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,28.526,0)"><path d="M535 230V280H52V230H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,36.157,0)"><path d="M729 650H468V622C546 615 554 610 554 527V365H213V527C213 610 221 616 297 622V650H38V622C120 616 128 611 128 527V123C128 39 120 34 40 28V0H303V28C221 34 213 40 213 123V322H554V123C554 39 546 34 460 28V0H728V28C647 34 639 39 639 123V527C639 610 647 615 729 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,46.153,0)"><path d="M535 230V280H323V490H265V280H52V230H265V-3H323V230H535Z"></path></g></svg> exchanger regulatory factor; IL-13: interleukin-13; P: phosphorylate; STAT6: signal transducers and activators of transcription 6; Foxj1: forkhead box protein J1; PKA: protein kinase A; NHERF2: NHE3 kinase; cAMP: cyclic adenosine monophosphate; CFTR: cystic fibrosis transmembrane conductance regulator.</div>

Mediators of Inflammation

Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

Figure 3