Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

Table 1

Posttranslational modifications of ezrin protein.

Phosphorylation site	Kinases/phosphorylation factors	Biological effects	References
Serine-66	Protein kinase A (PKA)	Mediate the remodeling of the apical membrane cytoskeleton	[64]
Tyrosine-145, 146	Src	Participate in cell proliferation, adhesion, and migration	[56, 57]
Tyrosine-190	Src Homology-2 (SH2)	A docking point, the premise for phosphorylation of Tyrosine-145	[24]
Threonine-235	Cyclin-dependent kinase 5 (CDK5)	Cooperates with Threonine-576	[23, 55]
Tyrosine-270	—	Affect the FERM-membrane interaction	[30]
Tyrosine-291	—	Weaken the FERM and C-terminal interaction	[30]
Tyrosine-353	Phosphoinositide 3-kinase (PI3-kinase) PI3-kinase/Akt pathway	Participate in the reorganization of the actin cytoskeleton	[58–60]
Tyrosine-354	—	Link to mobility and cellular adhesion	[57, 61]
Tyrosine-477	Src, epidermal growth factor (EGF)	Promotes the cell diffusion	[62, 63]
Serine-535, 536	Bach2	Weaken the FERM and C-terminal interaction	[30, 65]
Threonine-567	Phosphatidylinositol 4,5-bisphosphate (PIP2); Nck-interacting kinase (NIK); G protein-coupled receptor kinase 2 (GRK2)	Uncoupling of FERM and C-terminal domains	[51–53]
Arginine579; Glu244	—	Form a tight salt bridge	[30]