Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling

Table 2

Regulation of ezrin by other proteins.

Proteins	Biological effects	References
Intracellular adhesion molecules-1 (ICAM-1); Intracellular adhesion molecules-1 (ICAM-2)	PIP2 binds to cytoplasmic tails of ICAM-1, -2, forming ezrin-multiprotein-complexes	[81]
CD44	The cytoplasmic tail of CD44 forms a complex with FERM or with the full-length ezrin	[82]
CD43	Regulates T-cell trafficking through Ser76 within its cytoplasmic tail	[83]
E-cadherin	Activate GTPase Rac1	[84]
Na+/H+ exchanger 1 (NHE1)	Activate and target ezrin to specific plasma membrane domains, regulate cell survival	[85, 86]
exchanger regulatory factor (NHERF1)/ERM-binding phosphoprotein 50 (EBP50); NHE3 kinase (E3KARP)/NHERF2	Anchor to the plasma membrane using postsynaptic density proteins	[23, 87]
Protein kinase A (PKA); Cystic fibrosis transmembrane conductance regulator (CFTR)	PKA associates with CFTR via interaction with ezrin	[88]