Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse

Figure 1

Mito-TEMPO mitigates liver injury in LPS-induced sepsis mice. (a) Serum ALT and AST levels of LPS-induced sepsis mice. (b) Scoring and representative pictures of hepatic H&E staining (, 50 μm). Liver injury scores were estimated by the following six indicators: vacuolization, nuclear condensation, nuclear fragmentation, nuclear fading, erythrocyte stasis, and inflammatory cell infiltration. Scores were assigned based on the percentage of cells showing these phenomena in five microscopic fields (×200) as follows: , , , and . The six subscores were summed; the higher the total score, the more severe the injury. (c) The TUNEL-positive cells in the liver of LPS-induced sepsis mice (, 20 μm). The proportion of positive cells was assessed in five random fields (×200). per group. Data are presented as the from at least three independent experiments. , , , and .

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