Identification of Diagnostic Genes and Effective Drugs Associated with Osteoporosis Treatment by Single-Cell RNA-Seq Analysis and Network Pharmacology

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_center" colspan="3">Osteoporosis/osteoarthritis</td></tr><tr class="thead"><td class="align_left">cell_name</td><td class="align_center"><span style="width: 25.9492ptpx;"><svg height="12.7373pt" id="M12" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 25.9492 12.7373" width="25.9492pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.71,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.674,0)"><path d="M478 437H300V411C357 404 363 393 347 345C325 280 293 190 258 107C229 178 188 284 163 354C147 397 149 405 203 411V437H-2V411C52 403 59 396 82 339C130 222 176 109 220 -11H248C304 138 356 261 390 336C417 395 425 404 478 411V437Z"></path></g><g transform="matrix(.013,0,0,-0.013,16.693,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 365 44 353 44 339C44 315 69 296 87 296C101 296 111 303 116 319C124 349 133 371 145 385C156 397 171 404 190 404C241 404 275 364 275 291V274C253 256 180 229 120 209C65 190 39 159 39 110C39 47 88 -12 159 -12C189 -12 237 25 277 52C282 35 288 21 301 8C312 -3 333 -12 348 -12L433 39ZM275 84C256 65 221 48 195 48C164 48 124 73 124 124C124 161 146 180 185 198C206 208 254 229 275 240V84Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.466,0)"><path d="M238 0V26C174 32 166 38 166 104V712C132 700 70 683 18 677V653C81 647 87 645 87 577V104C87 38 78 32 15 26V0H238Z"></path></g></svg></span></td><td class="align_center">fc</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">CD45+ BM-MSCs_1</td><td class="align_center">1.03E-64</td><td class="align_center">1.952078384</td></tr><tr><td class="align_left">CD45- BM-MSCs_6</td><td class="align_center">1.29E-43</td><td class="align_center">40.55324249</td></tr><tr><td class="align_left">CD45+ BM-MSCs_4</td><td class="align_center">0.045726035</td><td class="align_center">0.861342268</td></tr><tr><td class="align_left">CD45+ BM-MSCs_2</td><td class="align_center">0.185992587</td><td class="align_center">0.934653196</td></tr><tr><td class="align_left">CD45- BM-MSCs_2</td><td class="align_center">1.50E-25</td><td class="align_center">0.584120062</td></tr><tr><td class="align_left">CD45- BM-MSCs_3</td><td class="align_center">5.45E-21</td><td class="align_center">0.489261845</td></tr><tr><td class="align_left">CD45- BM-MSCs_1</td><td class="align_center">3.69E-11</td><td class="align_center">1.274037866</td></tr><tr><td class="align_left">CD45- BM-MSCs_4</td><td class="align_center">0.175479663</td><td class="align_center">0.898346627</td></tr><tr><td class="align_left">CD45+ BM-MSCs_3</td><td class="align_center">8.77E-05</td><td class="align_center">0.765464953</td></tr><tr><td class="align_left">CD45+ BM-MSCs_5</td><td class="align_center">1.89E-48</td><td class="align_center">0.249892213</td></tr><tr><td class="align_left">CD45+ BM-MSCs_6</td><td class="align_center">0.52377383</td><td class="align_center">1.073767195</td></tr><tr><td class="align_left">CD45- BM-MSCs_5</td><td class="align_center">1.76E-21</td><td class="align_center">0.309302402</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Differential analysis of cell types.</div>

Mediators of Inflammation

tab1

Table 1

Table 1: Identification of Diagnostic Genes and Effective Drugs Associated with Osteoporosis Treatment by Single-Cell RNA-Seq Analysis and Network Pharmacology 

Table 1 | Identification of Diagnostic Genes and Effective Drugs Associated with Osteoporosis Treatment by Single-Cell RNA-Seq Analysis and Network Pharmacology 