The Colombian Strain of Trypanosoma cruzi Induces a Proinflammatory Profile, Neuronal Death, and Collagen Deposition in the Intestine of C57BL/6 Mice Both during the Acute and Early Chronic Phase

Figure 3

Intestinal photomicrographs of the intestinal histopathological differences between the noninfected, acute, and early chronic phases of T. cruzi Colombian strain infected C57Bl/6 mice. Intestinal inflammatory infiltrate (HE): (a) acute phase and (b) early chronic phase. (c) Intestinal amastigote nest in the acute phase highlighted by yellow lines (GIEMSA). Intestinal nerve ganglia (GIEMSA): (d) the two intestinal nerve ganglia of the myenteric plexus of uninfected mice highlighted using black lines (30 days); nervous ganglion without borderline of infected mice in the (e) acute and (f) early chronic phase with neuron (white arrow) and inflammatory cells (red arrow) remarkably close. Intestinal collagen deposition (Picrosirius): (g) noninfected, (h) acute, and (i) early chronic phase of infection.

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