Research Article
Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response
Figure 4
Quercetin significantly reversed BCRD-induced cell pyroptosis. Neurons were divided into BCRD, BCRD+quercetin, or BCRD+Pac+Flu. (a) The viability of neurons was assessed by the CCK8 assay. (b–d) The levels of NLRP3, ASC, and caspase-1 in neurons were investigated by RT-qPCR. (e) ASC, NLRP3, and caspase-1 levels in neurons were investigated by western blot. β-Actin was applied for quantification. (f) The pyroptosis of hippocampal neurons was evaluated by EthD-III staining compared with control. # compared with BCRD.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |