Roles Played by the PI3K/Akt/HIF-1α Pathway and IL-17A in the Chinese Subtype of Chronic Sinusitis with Nasal Polyps

Figure 4

The expressions of the PI3K/Akt/HIF-1α pathway in fibroblasts from nasal polyps. (a) The protein levels of HIF-1α, p-Akt, and PI3K in nasal polyp fibroblasts were detected by the WB method. (b) After TNF-α stimulation, the HIF-1α, p-Akt, and PI3K protein levels were significantly increased in nasal polyp fibroblasts. . After treatment with Wortmannin, the HIF-1α, p-Akt, and PI3K protein levels were significantly decreased in nasal polyp fibroblasts. . (c) Expression of HIF-1α mRNA in fibroblasts of nasal polyps. After TNF-α stimulation, the HIF-1α mRNA level was significantly increased in nasal polyp fibroblasts. . After treatment with Wortmannin, the HIF-1α mRNA level was significantly reduced in nasal polyp fibroblasts. . .

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