Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 2

The effects of statin therapy on hs-CRP and CRP levels in overall population and subgroup analyses.

Parameter		Number of arms	Weighted mean difference	95% CI ( value)	Test of heterogeneity
					(%)
hs-CRP
Overall		26	-0.97	-1.26, -0.68 (<0.001)	98.2	<0.001
Dosage category
High intensity		8	-2.05	-3.28, -0.82 (<0.001)	91.2	<0.001
Treatment duration (weeks)	≤10	5	-2.20	-4.59, 0.20 (0.07)	92.7	<0.001
	>10	3	-2.13	-3.39, -0.86 (0.001)	86.1	<0.001
Hydrophilicity/lipophilicity	Hydrophilic	3	-4.19	-9.10, 0.73 (0.09)	94.4	<0.001
	Lipophilic	5	-1.55	-3.02, -0.09 (0.03)	90.8	<0.001
Moderate/low intensity		16	-0.59	-0.92, -0.26 (0.02)	98.8	<0.001
Treatment duration (weeks)	≤10	5	-3.67	-10.94, -0.43 (0.32)	79	<0.001
	>10	11	-0.57	-0.90, -0.25 (0.001)	99.1	<0.001
Hydrophilicity/lipophilicity	Hydrophilic	4	-0.41	-1.64, 0.81 (0.50)	99.4	<0.001
	Lipophilic	11	-0.49	-0.67, -0.30 (0.001)	88.1	<0.001
CRP
Overall		20	-3.05	-4.86, -1.25 (<0.001)	99.2	<0.001
Dosage category
High intensity		11	-2.70	-5.467, 0.06 (0.05)	86.4	<0.001
Hydrophilicity/lipophilicity	Hydrophilic	3	1.19	-7.13, 9.51 (0.77)	66.8	<0.001
	Lipophilic	8	-3.82	-7.38, -0.26 (0.03)	90.9	<0.001
Moderate intensity		5	-2.69	-6.12, 0.74 (0.12)	99.2	<0.001