Limb-Bud and Heart (LBH) Upregulation in Cardiomyocytes under Hypoxia Promotes the Activation of Cardiac Fibroblasts via Exosome Secretion

Figure 7

Schematic summary of exosomal LBH related signaling in the post-MI cardiac microenvironment. The LBH-CRYAB signaling responsible for modulating the proliferation, transdifferentiation, and migration of CFs could be induced by exosome secretion from LBH-upregulated CMs under hypoxia.