Cell-Free DNA, Neutrophil extracellular traps (NETs), and Endothelial Injury in Coronavirus Disease 2019– (COVID-19–) Associated Acute Kidney Injury

Table 3

Correlation between cell-free DNA (cfDNA) and markers of AKI, TMA, inflammation, and NETs components.

Correlated to cfDNA	Spearman’s correlation	Value
ED creatinine	0.426	0.002
NGAL	0.545	<0.001
Cystatin C	0.330	0.022
ADAMTS13	-0.209	0.146
VWF	0.393	0.005
ADAMTS13/VWF	-0.433	0.002
C3a	0.625	<0.001
C3a/C3	0.620	<0.001
CRP	0.625	<0.001
Ferritin	0.454	0.001
IL-6	0.665	<0.001
IL-8	0.442	0.001
IL-10	0.462	0.001
Plasminogen	0.053	0.716
Fibrinogen	0.366	0.020
PAI-1	0.173	0.231
LDH	0.563	<0.001
Angiopoietin 1	0.082	0.576
Angiopoietin 2	0.279	0.052
Lymphocytes	-0.368	0.011
Neutrophils	0.281	0.048
NLR	0.402	0.005
C5a	0.450	0.001
Sc5b9	0.462	0.001
Haptoglobin	0.508	<0.001
TNFalpha	0.309	0.031
Elastase (ng/mL)	0.521	<0.001
Myeloperoxidase (ng/mL)	0.438	0.002
Platelets	-0.282	0.055

AKI, acute kidney injury; cfDNA, cell-free DNA; CRP, C-reactive protein; ED, emergency department; LDH, lactate dehydrogenase; NGAL, neutrophil gelatinase–associated lipocalin; VWF, von-Willebrand factor.