Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells

<div>Decrease of Atg13 inhibits autophagy and promotes LPS-induced inflammatory responses in LX2 cells. (a) Atg13 siRNA successfully decreased expression of Atg13. (b–d) Decrease of Atg13 inhibited autophagy and promoted LPS (1 <i>μ</i>g/mL, 0-4 h)-induced NLRP3 inflammasome activation and IL-1<i>β</i> secretion.</div>

Mediators of Inflammation

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Figure 6

Figure 6: Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells 

Figure 6 | Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells 