Research Article
Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells
Figure 7
LPS promotes inflammation and induces Atg13 loss via p38 MAPK. (a, b) SB203580 (5 μM) alleviated while Anisomycin (10 μM) promoted LPS (1 μg/mL, 4 h)-induced decrease of Atg13 (e, f). (c) SB203580 (5 μM) alleviated LPS (1 μg/mL, 4 h)-induced IL-1β secretion. (d, e) Neither SP600125 (40 μM) nor LY3214996 (5 nM) altered expression of Atg13.
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