Inflammatory Bowel Disease Therapeutics: A Focus on Probiotic Engineering

Figure 1

A model of cytokine-driven/targeted probiotic engineering. The promotor-driven expression of anti-inflammatory cytokines or antimicrobial peptides by the engineered probiotics may facilitate epithelial wound repair and the differentiation/reformation of mucosal barrier through inhibiting the infiltration of inflammation causing immune cells, thereby decreasing both intestinal and systemic inflammation.