CD4⁺ T Cells Promote IgG Production in MHC-Independent and ICAM-1-Dependent Manners in Pristane-Induced Lupus Mice

Figure 1

Serum immunoglobulin levels in pristane-induced lupus-like mice. Sera were collected before the injection and at 6 months post-PBS or pristane treatment. The levels of total IgG (a), total IgM (b), IgG2a (c), and anti-P0 (d), anti-SnRNP (e), and anti-dsDNA (f) autoantibodies in the serum were determined by an ELISA assay. Furthermore, the kidneys were collected when the mice were sacrificed at 6 months after PBS/pristane injection. The deposition of immune complexes (g) in the kidney was detected by the immunofluorescence assay. (h) Statistic analysis of immune complexes in the kidneys. Data were pooled from three independent experiments with 5 mice per group in each experiment. ; ; ; .

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