CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its Association with Immune Infiltrates in Ovarian Cancer

Table 2

Univariate and multivariate analysis of overall survival in patients with ovarian cancer.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	377
≤60	206	Reference
>60	171	1.355 (1.046-1.754)	0.021	1.410 (1.088-1.828)	0.009
FIGO stage	374
Stage I and stage II	24	Reference
Stage III and stage IV	350	2.115 (0.938-4.766)	0.071	2.122 (0.942-4.781)	0.070
Histologic grade	367
G1 and G2	46	Reference
G3 and G4	321	1.229 (0.830-1.818)	0.303
Lymphatic invasion	148
No	48	Reference
Yes	100	1.413 (0.833-2.396)	0.200
CLDN4	377
Low	187	Reference
High	190	1.647 (1.263-2.147)	<0.001	1.693 (1.297-2.209)	<0.001