CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its Association with Immune Infiltrates in Ovarian Cancer

Table 3

Univariate and multivariate analysis of disease-specific survival in patients with ovarian cancer.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	352
≤60	196	Reference
>60	156	1.255 (0.950-1.658)	0.110
FIGO stage	350
Stage I and stage II	23	Reference
Stage III and stage IV	327	2.276 (0.935-5.541)	0.070	2.283 (0.938-5.555)	0.069
Histologic grade	342
G1 and G2	42	Reference
G3 and G4	300	1.394 (0.893-2.178)	0.144
Lymphatic invasion	144
No	48	Reference
Yes	96	1.397 (0.810-2.408)	0.229
CLDN4	352
Low	183	Reference
High	169	1.554 (1.171-2.063)	0.002	1.553 (1.170-2.061)	0.002