Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice

Figure 7

IL-17A concentrations in SMC culture supernatants in vivo and in vitro. (a) Altered levels of IL-17A in SMC culture supernatants. There were significant differences among the three groups (, , one-way ANOVA). EAT-B mice had lower IL-17A concentrations than EAT-A mice ( vs. , ), and both EAT-A and EAT-B mice had higher IL-17A concentrations than NC mice (, both ). (b) Dose-dependent alterations of IL-17A levels in SMC culture supernatants after treatment with different concentrations of DAPT (, , one-way ANOVA).

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