IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway

Figure 2

Immunohistochemical staining images of joint fibrosis in different groups (×400 magnification). (a, c) The results of immunohistochemical staining of type I collagen and type III collagen in joint fibrotic tissue. (b, d) The positive expression of collagen immunohistochemical staining in the IFN-α-2b group was significantly reduced. IFN-α-2b effectively inhibits the formation of collagen I and collagen III in fibrotic tissues. (e) The result of Sirius red staining was visualized by polarized light microscope, in which type I collagen was yellow and type III collagen was green. The image shows that collagen fibers decrease with increasing drug concentration. (f, h) Immunohistochemical staining image of PCNA and α-SMA. (g, i) The IFN-α-2b medication group can significantly reduce the expression of PCNA and α-SMA. Compared with the control group. Comparison between the two groups of IFN-α-2b medications, ().