IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway

Figure 6

IFN-α-2b inhibits the migration of fibroblasts by STAT1/P21 signaling pathway. (a, b) In vitro wound healing experiments showed that the IFN-α-2b treatment group significantly inhibited the migration rate of fibroblasts. (c, d) Compared with the control group, the number of cells passing through the cell bottom membrane in the IFN-α-2b treatment group was significantly reduced. And it is concentration-dependent. (e, f) Western blotting shows that the IFN-α-2b treatment group can reduce the relative expression level of α-SMA, while the fludarabine and IFN-α-2b coapplication groups can partially reverse the above-mentioned inhibitory trend of IFN-α-2b. Each sample randomly selects 10 microscope fields and conducts 3 independent experiments. Compared with the control group. Compared between the two groups, ().

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