Research Article
HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway
Figure 3
HMGB2 depletion suppressed Ang-II-caused ferroptosis in VSMCs. DHE staining was used to detect ROS generation (a). Mitochondrial status was observed under TEM in Ang-II-induced VSMCs (b). Fe2+ level, GPX4, FTH1, ACSL4, and COX2 level were detected in Ang-II-induced VSMC transfected with shNC, or shHMGB2#3 (c and d).
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