TIRAP, TRAM, and Toll-Like Receptors: The Untold Story

Figure 5

Emerging model for TLR signaling. Recent data suggest a new model according to which all TLRs, but TLR3, are TIRAP-dependent for MyD88-mediated pathways and TRAM-dependent for the TRIF cascade. TLR3 directly recruits the TRIF adaptor to the endosomal compartment. TRAF3: TNF receptor-associated factor 3.