Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism

Figure 3

Resveratrol ameliorates the phenotype of interleukin-1β-induced chondrocytes via the SIRT1-FoxO1 pathway. (a, b) Western blot to detect the expression levels of the chondrocyte phenotype-related genes MMP13, ADAMS5, COL-II, and SOX6. (c–h) The mRNA levels of SIRT1, p-FoxO1/FoxO1, MMP13, ADAMTS5, COL-II, and SOX6 were detected by reverse transcription-quantitative polymerase chain reaction. The values represent the deviation of three independent experiments. , , , , and ns: not significant.

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