Resveratrol Improves the Progression of Osteoarthritis by Regulating the SIRT1-FoxO1 Pathway-Mediated Cholesterol Metabolism

Figure 5

Resveratrol ameliorates IL-1β-induced chondrocytes cholesterol efflux via the SIRT1-FoxO1 pathway. (a–d) Western blot analysis of protein expression levels of LXRα, ABCA1, and ApoA1. (e–g) Levels of ABCA1, ApoA1, and LXRα in each group of chondrocytes were quantified by qRT-PCR. (h, i) Free and total cholesterol profiles of chondrocytes in each group were analyzed using the respective cholesterol assay kits. The values represent the deviation of three independent experiments. , , , and .

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