Cell-Specific Regulation of Inflammatory Cytokines and Acute-Phase Proteins by the Glucocorticoid Receptor

Figure 4

Cellular mRNA levels in primary human hepatocytes, donor 1. Cells were treated with TNFα 50 ng/mL, LPS 10 ng/mL, and/or dexamethasone 0.1 or 1 µM for 24 hr. Gene expressions of (a) SAA1, (b) CD163, (c) IL1B, and (d) CCL2 were assessed by qPCR and normalized to AKIRIN1. Mean ± SE, n = 3 replicate wells. , , and . ns, not significantly different.

(a)

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