Cell-Specific Regulation of Inflammatory Cytokines and Acute-Phase Proteins by the Glucocorticoid Receptor

Figure 5

Chemokine protein levels in culture media of primary human hepatocytes, donor 2. Cells were treated with TNFα 50 ng/mL, LPS 10 ng/mL, dexamethasone 1 µM, and RU486 5 µM for 24 hr before media collection for ELISA assays of (a) CXCL1, (b) CXCL2, and (c) CXCL8. CXCL2 was log10 transformed for statistical analysis due to the large error bar in the TNF-LPS group. Mean ± SE, n = 4-well replicates, and , , and . ns, not significantly different.

(a)

(b)

(c)