Research Article

Exploration of Hub Genes and Pathogenetic Pathways in Systemic Lupus Erythematosus Complicated with Early Onset Atherosclerosis

Table 2

The details of the hub genes.

No.Gene symbolFull nameFunction

1PTPRCEncoding protein-tyrosine phosphatase receptor-type CPTPRC is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system

2TYROBPTransmembrane immune signaling adaptor TYROBPThe encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element

3FCGR3AFc gamma receptor IIIaThis gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen–antibody complexes from the circulation

4ITGAXIntegrin subunit alpha XThis gene encodes the integrin alpha X chain protein

5LCP2Lymphocyte cytosolic protein 2Participates in immune response and intracellular signal transduction

6IL1BInterleukin 1 betaThis cytokine is an important mediator of the inflammatory response and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis

7IRF8Interferon regulatory factor 8Plays critical roles in interferon (IFN) signaling pathways governing the establishment of innate immune responses by myeloid and dendritic cells

8LILRB2Leukocyte immunoglobulin-like receptor B2Control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity

9CD68CD68 moleculeClear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages

10C1QBComplement C1q B chainPlays an important role in maintaining the stability of the body’s environment, oxidative stress, glucose and lipid metabolism, and other processes

11CCR7C–C motif chemokine receptor 7This receptor was identified as a gene induced by the Epstein–Barr virus (EBV), controls the migration of memory T cells to inflamed tissues, as well as stimulates dendritic cell maturation

12C1QAComplement C1q A chainPlays an important role in maintaining the stability of the body’s environment, oxidative stress, glucose and lipid metabolism, and other processes