Research Article
Exploration of Hub Genes and Pathogenetic Pathways in Systemic Lupus Erythematosus Complicated with Early Onset Atherosclerosis
Table 3
Key transcriptional factors (TFs) of hub genes.
| Key TF | Description | p-Value | Genes |
| SPI1 | Spleen focus forming virus (SFFV) proviral integration oncogene spi1 | 7.27E-06 | IL1B, CD68, ITGAX | TRERF1 | Transcriptional regulating factor 1 | 7.77E-06 | CCR7, LILRB2 | IRF8 | Interferon regulatory factor 8 | 2.03E-05 | IL1B, CD68 | ESR2 | Estrogen receptor 2 (ER beta) | 6.30E-05 | CD68, PTPRC | WT1 | Wilms tumor 1 | 0.00058 | ITGAX, IRF8 | RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.000794 | IL1B, CCR7, ITGAX | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.00081 | ITGAX, IL1B, CCR7 | STAT1 | Signal transducer and activator of transcription 1, 91 kDa | 0.00126 | IL1B, IRF8 | JUN | Jun proto-oncogene | 0.00388 | IL1B, ITGAX |
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