Exploration of Hub Genes and Pathogenetic Pathways in Systemic Lupus Erythematosus Complicated with Early Onset Atherosclerosis

Table 3

Key transcriptional factors (TFs) of hub genes.

Key TF	Description	p-Value	Genes
SPI1	Spleen focus forming virus (SFFV) proviral integration oncogene spi1	7.27E-06	IL1B, CD68, ITGAX
TRERF1	Transcriptional regulating factor 1	7.77E-06	CCR7, LILRB2
IRF8	Interferon regulatory factor 8	2.03E-05	IL1B, CD68
ESR2	Estrogen receptor 2 (ER beta)	6.30E-05	CD68, PTPRC
WT1	Wilms tumor 1	0.00058	ITGAX, IRF8
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.000794	IL1B, CCR7, ITGAX
NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.00081	ITGAX, IL1B, CCR7
STAT1	Signal transducer and activator of transcription 1, 91 kDa	0.00126	IL1B, IRF8
JUN	Jun proto-oncogene	0.00388	IL1B, ITGAX