Attenuation of Inflammatory Responses in Breast and Ovarian Cancer Cells by a Novel Chalcone Derivative and Its Increased Potency by Curcumin

Figure 4

MDA-MB-231 breast cancer cell line and SKOV3 ovarian cancer cell line were treated with LPS to induce inflammation and subsequently were treated with different concentrations of MPP with or without curcumin. Subsequently, the levels of secreted cytokines were measured in the cell culture supernatant. The levels of IL-1β in (a) MDA-MB-231 and (b) SKOV3 cells; the levels of IL-6 in (c) MDA-MB-231 and (d) SKOV3 cells; and the levels of TNF-α in (e) MDA-MB-231 and (f) SKOV3 cells were measured. ^### compared with unstimulated untreated control cells; asterisks indicate comparison with LPS-stimulated untreated cells (, , and ). The results are of at least three independent experiments.

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