Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Table 2

Cox regression analysis for CHF.

Variables	Unadjusted		Adjusted^a
	HR (95% CI)		HR (95% CI)
Serum MMP7 (ng/ml)	1.089 (1.024-1.159)	0.006	1.093 (1.015-1.177)	0.02
Ln dialysate MMP7 (pg/ml)	1.558 (1.212-2.002)	0.001	1.567 (1.137-2.159)	0.006
Age (y)	0.986 (0.972-1.001)	0.08	0.997 (0.982-1.014)	0.77
Male	0.895 (0.609-1.314)	0.57	0.987 (0.576-1.691)	0.96
BMI (kg/m^2)	1.003 (0.986-1.020)	0.73	0.993 (0.972-1.013)	0.49
Baseline LVEF, %	0.960 (0.941-0.980)	<0.001	0.966 (0.943-0.989)	0.004
Mean dialysate GLUC, %	2.669 (1.006-7.077)	0.050	2.384 (0.716-7.944)	0.16
Baseline UF (ml)	1.000 (0.999-1.000)	0.56	0.999 (0.999-1.000)	0.12
Mean serum ALB (g/l)	0.946 (0.907-0.987)	0.01	0.992 (0.942-1.044)	0.75
Loss of RRF	1.869 (1.259-2.776)	0.002	1.794 (1.123-2.864)	0.01
TKT/V	1.049 (0.822-1.338)	0.70	1.098 (0.758-1.590)	0.62

Ln dialysate MMP7, BMI, and TKT/V were calculated by the formulas mentioned before. Dialysate glucose concentration, urine volume, serum ALB, and TKT/V were the average values during the first 12 months after dialysis. CHF: congestive heart failure; MMP7: matrix metalloproteinase-7; BMI: body mass index; LVEF: left ventricular ejection fraction; GLUC: glucose concentration; UF: ultrafiltration; ALB: albumin; RRF: residual renal function; HR: hazard ratio; CI: confidence interval. ^aAdjusted with age, sex, BMI, baseline LVEF, baseline UF, baseline total KT/V, loss of residual renal function, mean dialysate glucose concentration, and serum ALB of the first 12 months after dialysis.