Association between the Systemic Immune-Inflammation Index and Thyroid Function in U.S. Adults
Table 3
Weighted multivariate linear regression analysis between lnSII and thyroid function.
Model 1aβ (95% CI), p-value
Model 2bβ (95% CI), p-value
Model 3cβ (95% CI), p-value
FT3
lnSII
−0.0603 (−0.1078, −0.0128)
−0.0496 (−0.0991, −0.0002)
−0.0559 (−0.1060, −0.0059)
Tertile 1
Reference
Reference
Reference
Tertile 2
−0.0242 (−0.0588, 0.0104)
−0.0131 (−0.0467, 0.0205)
−0.0180 (−0.0532, 0.0172)
Tertile 3
−0.0535 (−0.0851, −0.0218)
−0.0321 (−0.0626, −0.0015)
−0.0385 (−0.0689, −0.0082)
p for trend
0.002
0.044
0.019
TT4
lnSII
0.1837 (0.0974, 0.2700)
0.1692 (0.0873, 0.2510)
0.1499 (0.0722, 0.2276)
Tertile 1
Reference
Reference
Reference
Tertile 2
0.0526 (−0.0504, 0.1555)
0.0395 (−0.0650, 0.1439)
0.0404 (−0.0656, 0.1464)
Tertile 3
0.2267 (0.1199, 0.3334)
0.1885 (0.0850, 0.2921)
0.1637 (0.0638, 0.2636)
p for trend
<0.001
<0.001
0.004
FT3/FT4
lnSII
−0.0918 (−0.1658, −0.0178)
−0.0724 (−0.1477, 0.0029)
−0.0920 (−0.1667, −0.0173)
Tertile 1
Reference
Reference
Reference
Tertile 2
−0.0078 (−0.0583, 0.0427)
0.0130 (−0.0376, 0.0635)
−0.0119 (−0.0635, 0.0396)
Tertile 3
−0.0761 (−0.1349, −0.0172)
−0.0403 (−0.0980, 0.0175)
−0.0635 (−0.1191, −0.0078)
p for trend
0.014
0.174
0.034
TG
lnSII
1.8916 (−0.0697, 3.8529)
2.1148 (0.1579, 4.0716)
1.6395 (−0.1964, 3.4754)
Tertile 1
Reference
Reference
Reference
Tertile 2
0.1784 (−1.6907, 2.0476)
0.5005 (−1.3938, 2.3949)
0.1917 (−1.7884, 2.1718)
Tertile 3
3.6951 (0.6535, 6.7366)
3.7026 (0.6588, 6.7463)
3.1108 (0.2400, 5.9817)
p for trend
0.021
0.022
0.045
TPOAb
lnSII
5.1330 (0.4263, 9.8398)
3.7777 (−1.0059, 8.5613)
4.0172 (−0.5236, 8.5581)
Tertile 1
Reference
Reference
Reference
Tertile 2
0.8370 (−6.0170, 7.6911)
−0.3275 (−7.6876, 7.0326)
−0.7054 (−8.0546, 6.6439)
Tertile 3
5.5685 (−1.4221, 12.5590)
3.7000 (−3.4980, 10.8980)
3.6992 (−3.0884, 10.4868)
p for trend
0.123
0.313
0.288
Note: FT3, free triiodothyronine; FT4, free thyroxine; TT3, total triiodothyronine; TT4, total thyroxine; TG, thyroglobulin; TGAb, thyroglobulin antibodies; and TPOAb, thyroid peroxidase antibodies. aModel 1: no covariates were adjusted. bModel 2: adjusted for age, sex, race, marital status, family poverty income ratio, and education level. cModel 3: adjusted for age, sex, race, marital status, family poverty income ratio, education level, body mass index, smoking status, alcohol use, diabetes, glycated hemoglobin, alanine aminotransferase, aspartate aminotransferase, creatinine, urine iodine concentration, and total cholesterol. , , . Bold values signify the statistically significant variables clearly distinguishable from those that are not.
