Research Article
Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis
Table 1
Correlation analysis of plasma mCRP levels and urinary mCRP levels with clinicopathological data in lupus nephritis.
| | Clinicopathological data | Plasma mCRP levels | Urinary mCRP levels | | r value (95% CI) | P value | r value (95% CI) | P value |
| | Clinical data | | Age (years) | −0.087 (−0.289 to 0.120) | 0.403 | 0.155 (−0.031 to 0.339) | 0.133 | | SLEDAI | 0.202 (−0.002 to 0.392) | 0.050 | 0.138 (−0.070 to 0.326) | 0.183 | | Hemoglobin (g/l) | −0.178 (−0.359 to 0.025) | 0.085 | −0.066 (−0.276 to 0.152) | 0.524 | | Urine protein (g/24 hr) | 0.073 (−0.117 to 0.276) | 0.480 | 0.132 (−0.062 to 0.311) | 0.202 | | Serum creatinine (μmol/l) | 0.194 (−0.006 to 0.378) | 0.060 | 0.460 (0.292 to 0.604) | <0.001 | | Serum C3 (g/l) | 0.005 (−0.208 to 0.214) | 0.959 | −0.062 (−0.266 to 0.144) | 0.554 | | Serum C4 (g/l) | 0.064 (−0.134 to 0.275) | 0.540 | 0.051 (−0.144 to 0.253) | 0.622 | | Renal histopathology indices | | Endocapillary hypercellularity | −0.005 (−0.192 to 0.188) | 0.964 | 0.216 (0.031 to 0.405) | 0.036 | | Neutrophils/karyorrhexis | −0.072 (−0.275 to 0.122) | 0.490 | 0.092 (−0.093 to 0.268) | 0.377 | | Fibrinoid necrosis | 0.152 (−0.044 to 0.357) | 0.142 | −0.025 (−0.247 to 0.167) | 0.808 | | Cellular–fibrocellular crescents | 0.063 (−0.056 to 0.304) | 0.545 | 0.040 (−0.178 to 0.241) | 0.698 | | Subendothelial hyaline deposits | −0.022 (−0.201 to 0.161) | 0.833 | 0.131 (−0.072 to 0.342) | 0.204 | | Interstitial inflammatory cell infiltration | 0.014 (−0.206 to 0.231) | 0.895 | 0.514 (0.363 to 0.655) | <0.001 | | Activity indices score | 0.110 (−0.082 to 0.315) | 0.289 | 0.214 (0.009 to 0.420) | 0.038 | | Glomerular sclerosis | −0.115 (−0.288 to 0.079) | 0.265 | 0.241 (0.041 to 0.431) | 0.019 | | Fibrous crescents | −0.002 (−0.160 to 0.195) | 0.984 | 0.159 (−0.023 to 0.313) | 0.123 | | Tubular atrophy | −0.035 (−0.241 to 0.159) | 0.738 | 0.164 (−0.051 to 0.352) | 0.113 | | Interstitial fibrosis | 0.036 (−0.146 to 0.204) | 0.730 | 0.270 (0.065 to 0.460) | 0.008 | | Chronicity indices score | −0.047 (−0.242 to 0.153) | 0.653 | 0.292 (0.089 to 0.459) | 0.004 |
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mCRP, modified C reactive protein; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; 95% CI, 95% confidence interval. Bold values are statistically significant.
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