Heparin-Binding Protein in Bronchoalveolar Lavage Fluid as a Biomarker for Discriminating Severe Bacterial and Viral Pneumonia in Critically Ill Children

Table 3

Performance characteristics of biomarkers in blood and BALF for predicting bacterial pneumonia.

Biomarker	Cutoff value	AUC		95% CI	Sensitivity (%)	Specificity (%)
Blood N%	48.60%	0.621	0.010	0.532–0.710	68.25	56.36
Blood PCT	0.12 ng/mL	0.598	0.035	0.513–0.684	63.49	54.55
Blood HBP	50.80 ng/mL	0.851	<0.001	0.797–0.905	72.22	90.91
BALF N%	70.50%	0.942	<0.001	0.896–0.988	96.03	89.09
BALF IL-6	19.26 pg/mL	0.800	<0.001	0.732–0.867	81.75	63.64
BALF HBP	74.05 ng/mL	0.994	<0.001	0.987–1.001	95.24	100.00

HBP: heparin-binding protein; IL-6: interleukin-6; PCT: procalcitonin; N%: neutrophil percentage; BALF: bronchoalveolar lavage fluid; AUC: area under the curve; 95% CI: 95% confidence interval.