Fibrinogen Is Associated with Prognosis of Critically Ill Patients with Sepsis: A Study Based on Cox Regression and Propensity Score Matching

Table 1

Baseline characteristics of enrolled patients.

Characteristics	Total ()	Survivors ()	Nonsurvivors ()
Age, years	63.31 (16.41)	61.46 (16.93)	66.12 (15.17)	<0.001
Gender, (%)	1880 (55.90)	1149 (56.6)	731 (54.8)	0.328
Comorbidities, (%)
AKI	2355 (70.0)	1283 (63.2)	1072 (80.4)	<0.001
AMI	197 (5.9)	92 (4.5)	105 (7.9)	<0.001
Heart failure	990 (29.4)	562 (27.7)	428 (32.1)	0.007
Liver cirrhosis	562 (16.7)	256 (12.6)	306 (22.9)	<0.001
Hypertension	681 (20.2)	415 (20.4)	266 (19.9)	0.761
COPD	239 (7.1)	125 (6.2)	114 (8.5)	0.01
CKD	752 (22.3)	421 (20.7)	331 (24.8)	0.006
Atrial fibrillation	1121 (33.3)	618 (30.4)	503 (37.7)	<0.001
Cerebral infarction	151 (4.5)	88 (4.3)	63 (4.7)	0.653
Cerebral hemorrhage	47 (1.4)	23 (1.1)	24 (1.8)	0.144
Thrombosis	495 (14.7)	302 (14.9)	193 (14.5)	0.786
Acute respiratory failure	1804 (53.6)	936 (46.1)	868 (65.1)	<0.001
Laboratory examination
Fibrinogen (mg/dL)	412.6 (230.7)	451.30 (228.60)	353.79 (221.30)	<0.001
WBC, 10^9/L	14.3 (15.6)	14.11 (16.77)	14.58 (13.75)	0.399
Creatine, mEq/L	3.0 (2.4)	2.74 (2.52)	3.30 (2.19)	<0.001
Hemoglobin, g/dL	10.9 (2.5)	11.06 (2.46)	10.70 (2.48)	<0.001
Albumin, g/dL	2.9 (0.68)	2.97 (0.68)	2.78 (0.71)	<0.001
Platelet, 10^9/L	195.0 (130.3)	203.21 (131.68)	182.47 (127.19)	<0.001
Potassium, mEq/L	4.4 (1.0)	4.29 (0.98)	4.46 (1.02)	<0.001
Sodium, mEq/L	136.7 (6.7)	136.87 (6.52)	136.43 (7.05)	0.065
Lactate, mmol/L	3.3 (2.8)	2.82 (2.12)	3.98 (3.51)	<0.001
Bilirubin, mg/dL	3.0 (5.9)	2.30 (4.63)	4.06 (7.45)	<0.001
Glucose, mg/dL	150.7 (104.6)	149.60 (109.38)	152.31 (96.79)	0.461
PT, seconds	19.7 (13.5)	18.59 (12.99)	21.57 (14.23)	<0.001
APTT, seconds	37.7 (19.5)	35.52 (16.69)	41.40 (23.03)	<0.001
Score
SOFA	10.1 (4.8)	8.63 (4.34)	12.29 (4.70)	<0.001
SAPSII	47.7 (16.7)	42.90 (15.05)	54.98 (16.57)	<0.001
Treatment, (%)
Ventilator	3001 (89.2)	1769 (87.1)	1232 (92.4)	<0.001
RRT	730 (21.7)	415 (20.4)	315 (23.6)	<0.001