Fibrinogen Is Associated with Prognosis of Critically Ill Patients with Sepsis: A Study Based on Cox Regression and Propensity Score Matching

Table 4

Cox analysis of all included covariates.

	Univariate regression			Multivariate regression
	HR	95% CI	P	HR	95% CI	P
Age, years
18-40	—	—	—	—	—	—
40-60	1.73	1.35-2.22	<0.001	1.49	1.15-1.93	0.002
60-80	1.92	1.51-2.44	<0.001	1.98	1.54-2.55	<0.001
>80	2.55	1.97-3.30	<0.001	2.82	2.14-3.72	<0.001
Gender
Female	—	—	—	—	—	—
Male	0.95	0.85-1.05	0.305	0.90	0.80-1.01	0.064
Comorbidities (patients without comorbidities as baseline)
AMI	1.48	1.21-1.81	<0.001	1.17	0.95-1.43	0.15
Heart failure	1.14	1.01-1.27	0.03	0.97	0.86-1.11	0.69
Liver cirrhosis	1.70	1.50-1.94	<0.001	1.11	0.94-1.31	0.21
Hypertension	1.00	0.87-1.14	0.95	1.08	0.93-1.25	0.32
COPD	1.31	1.08-1.59	0.006	1.16	0.95-1.42	0.14
CKD	1.17	1.03-1.32	0.016	0.89	0.77-1.02	0.097
Atrial fibrillation	1.24	1.11-1.38	<0.001	1.01	0.90-1.15	0.85
Cerebral infarction	0.97	0.75-1.25	0.82	0.98	0.76-1.28	0.89
Cerebral hemorrhage	1.36	0.94-2.03	0.14	1.83	1.21-2.78	0.005
Thrombosis	0.91	0.78-1.06	0.24	0.90	0.77-1.05	0.17
Acute respiratory failure	1.80	1.61-2.01	<0.001	1.53	1.35-1.72	<0.001
AKI	1.98	1.73-2.26	<0.001	1.19	1.00-1.41	0.047
Laboratory examination (patients within normal range as reference)
Fibrinogen
<150 mg/dL	1.66	1.42-1.93	<0.001	1.22	1.03-1.44	0.022
>400 mg/dL	0.60	0.53-0.68	<0.001	0.66	0.59-0.75	<0.001
WBC, 10^9/L
<4	1.12	0.92-1.35	0.27	1.24	1.02-1.51	0.034
>11	1.09	0.97-1.22	0.17	1.06	0.94-1.20	0.31
Creatine, mEq/L	1.06	1.04-1.08	<0.001	1.50	1.20-1.88	<0.001
Hemoglobin, g/dL	1.29	1.15-1.46	<0.001	1.26	1.11-1.44	<0.001
Albumin, g/dL	0.72	0.66-0.77	<0.001	0.84	0.61-1.16	0.29
Platelet, 10^9/L
<150	1.31	1.17-1.46	<0.001	0.71	0.37-1.38	0.31
>400	0.65	0.65-1.05	0.12	1.10	0.96-1.27	0.18
Potassium, mEq/L
<3.3	0.94	0.80-1.10	0.41	0.94	0.80-1.11	0.49
>5.1	1.33	1.16-1.51	<0.001	1.11	0.97-1.28	0.12
Sodium, mEq/L
<133	1.21	1.08-1.35	0.001	1.15	1.03-1.30	0.016
>145	1.48	1.17-1.88	0.001	1.32	1.04-1.70	0.026
Lactate, mmol/L	1.13	1.11-1.16	<0.001	1.33	1.18-1.50	<0.001
Bilirubin, mg/dL	1.03	1.03-1.04	<0.001	1.09	0.96-1.25	0.19
Glucose, mg/dL
<70	1.81	1.43-2.30	<0.001	1.42	1.12-1.80	0.004
>105	0.96	0.85-1.10	0.54	0.99	0.87-1.13	0.87
PT, seconds
<10.4	0.65	0.33-1.26	0.20	0.71	0.37-1.38	0.31
>13.4	1.45	1.28-1.65	<0.001	1.10	0.96-1.27	0.18
APTT, seconds
<22	1.34	0.91-1.96	0.14	1.30	0.88-1.92	0.19
>35	1.74	1.57-1.95	<0.001	1.35	1.20-1.52	<0.001
Treatment
Ventilator	1.61	1.31-1.97	<0.001	1.10	0.89-1.36	0.40
RRT	1.80	1.60-2.02	<0.001	1.43	1.26-1.63	<0.001