Fibrinogen Is Associated with Prognosis of Critically Ill Patients with Sepsis: A Study Based on Cox Regression and Propensity Score Matching

Table 6

Subgroup analysis of the association between fibrinogen and inhospital mortality based on model 3.

Characteristics	N	Low fibrinogen HR (95% CI)		Elevated fibrinogen HR (95% CI)		for interaction
Age						0.43
<40	307	1.20 (0.61, 2.37)	0.60	0.71 (0.39, 1.32)	0.29
40-59	965	1.47 (1.12, 1.93)	0.006	0.68 (0.51, 0.90)	0.007
60-79	1543	1.05 (0.81, 1.38)	0.70	0.60 (0.50, 0.72)	<0.001
≥80	547	1.49 (0.91, 2.43)	0.11	0.85 (0.65, 1.11)	0.22
Gender						0.33
Female	1484	1.19 (0.93, 1.52)	0.17	0.61 (0.51, 0.74)	<0.001
Male	1878	1.25 (0.99, 1.58)	0.056	0.70 (0.59, 0.83)	<0.001
AMI						0.068
No	3165	1.23 (1.04, 1.46)	0.018	0.64 (0.56, 0.73)	<0.001
Yes	197	1.48 (0.71, 3.09)	0.29	1.01 (0.61, 1.67)	0.98
Heart failure						0.58
No	2372	1.18 (0.98, 1.43)	0.08	0.66 (0.56, 0.77)	<0.001
Yes	990	1.26 (0.86, 1.83)	0.23	0.64 (0.52, 0.80)	<0.001
Liver cirrhosis						0.88
No	2800	1.18 (0.94, 1.48)	0.16	0.66 (0.58, 0.75)	<0.001
Yes	562	1.31 (1.00, 1.71)	0.048	0.76 (0.48, 1.21)	0.25
Hypertension						0.88
No	2683	1.22 (1.02, 1.47)	0.031	0.65 (0.56, 0.74)	<0.001
Yes	679	1.26 (0.82, 1.94)	0.29	0.70 (0.53, 0.93)	0.013
COPD						0.63
No	3123	1.23 (1.03, 1.46)	0.019	0.67 (0.59, 0.77)	<0.001
Yes	239	1.11 (0.56, 2.22)	0.77	0.60 (0.373, 0.95)	0.029
CKD						0.92
No	2610	1.21 (1.00, 1.45)	0.049	0.67 (0.57, 0.77)	<0.001
Yes	752	1.33 (0.90, 1.98)	0.16	0.66 (0.52, 0.84)	0.001
Atrial fibrillation						0.004
No	2241	1.22 (1.01, 1.49)	0.044	0.58 (0.49, 0.69)	<0.001
Yes	1121	1.07 (0.76, 1.51)	0.69	0.81 (0.67, 0.98)	0.028
Cerebral infarction						0.001
No	3211	1.18 (1.00, 1.40)	0.053	0.63 (0.55, 0.72)	<0.001
Yes	151	6.90 (1.94, 24.51)	0.003	1.73 (0.87, 3.47)	0.12
Cerebral hemorrhage						0.59
No	3315	1.21 (1.03, 1.44)	0.024	0.67 (0.59, 0.76)	<0.001
Yes	47	5.25 (0.03.987.47)	0.54	0.21 (0.001, 55.66)	0.58
Thrombosis						0.13
No	2867	1.27 (1.06, 1.53)	0.009	0.68 (0.60, 0.78)	<0.001
Yes	495	0.90 (0.56, 1.45)	0.66	0.60 (0.43, 0.84)	0.003
Acute respiratory failure						0.004
No	1561	1.39 (1.04, 1.87)	0.029	0.52 (0.42, 0.64)	<0.001
Yes	1801	1.15 (0.94, 1.41)	0.19	0.76 (0.65, 0.88)	<0.001
Ventilator						0.103
No	364	2.43 (1.18, 5.02)	0.016	0.45 (0.28, 0.73)	0.001
Yes	2998	1.17 (0.99, 1.40)	0.073	0.68 (0.60, 0.78)	<0.001
RRT						0.33
No	2633	1.30 (1.05, 1.61)	0.016	0.68 (0.59, 0.79)	<0.001
Yes	729	1.02 (0.78, 1.34)	0.89	0.59 (0.46, 0.75)	<0.001
AKI						0.18
No	1009	1.80 (1.15, 2.81)	0.01	0.63 (0.48, 0.84)	0.001
Yes	2353	1.18 (0.98, 1.41)	0.078	0.94 (0.65, 1.35)	<0.001
WBC, 10^9/L						<0.001
4-11	1236	1.11 (0.84, 1.49)	0.47	0.53 (0.42, 0.66)	<0.001
< 4	323	1.11 (0.57, 2.15)	0.75	1.52 (0.98, 2.36)	0.061
> 11	1803	1.32 (1.05, 1.67)	0.019	0.65 (0.50, 1.08)	<0.001
Creatine, mEq/L						0.94
< 1.2	676	2.09 (1.04, 4.21)	0.039	0.62 (0.43, 0.90)	0.011
≥ 1.2	2686	1.20 (1.01, 1.43)	0.037	0.67 (0.59, 0.77)	<0.001
Hemoglobin, g/dL						0.29
< 12	1122	1.34 (0.97, 1.85)	0.072	0.66 (0.53, 0.83)	<0.001
≥ 12	2240	1.17 (0.96, 1.43)	0.11	0.66 (0.57, 0.77)	<0.001
Albumin, g/dL						0.50
< 3.5	114	0.81 (0.21, 3.16)	0.76	0.41 (0.16, 1.06)	0.067
≥ 3.5	3248	1.20 (1.02, 1.43)	0.033	0.67 (0.59, 0.76)	<0.001
Platelet, 10^9/L						0.07
150-400	1724	1.21 (0.88, 1.67)	0.24	0.73 (0.62, 0.87)	<0.001
< 150	1399	1.15 (0.94, 1.42)	0.18	0.53 (0.43, 0.66)	<0.001
> 400	239	24.88 (1.94, 319.14)	0.014	1.13 (0.60, 2.11)	0.707
Potassium, mEq/L						0.81
3.3-5.1	2198	1.13 (0.91, 1.40)	0.26	0.66 (0.57, 0.78)	<0.001
< 3.3	500	1.32 (0.86, 2.03)	0.21	0.71 (0.48, 1.04)	0.077
> 5.1	664	1.37 (0.95, 1.99)	0.094	0.64 (0.48, 0.84)	0.001
Sodium, mEq/L						0.45
133-145	1906	1.13 (0.88, 1.45)	0.35	0.68 (0.57, 0.80)	<0.001
< 133	1305	1.21 (0.96, 1.54)	0.11	0.60 (0.49, 0.74)	<0.001
> 145	151	2.35 (0.81, 6.84)	0.12	0.35 (0.16, 0.76)	0.007
Lactate, mmol/L						0.71
< 2	1292	1.31 (0.91, 1.89)	0.15	0.65 (0.52, 0.80)	<0.001
> 2	2070	1.15 (0.95, 1.40)	0.15	0.67 (0.58, 0.79)	<0.001
Bilirubin, mg/dL						0.002
< 1.5	2124	1.01 (0.73, 1.40)	0.95	0.74 (0.64, 0.86)	<0.001
≥ 1.5	1238	1.21 (0.99, 1.49)	0.068	0.52 (0.41, 0.66)	<0.001
Glucose, mg/dL						0.72
70-105	843	1.09 (0.78, 1.52)	0.62	0.67 (0.52, 0.88)	0.003
< 70	150	1.44 (0.78, 2.65)	0.25	0.85 (0.40, 1.81)	0.68
> 105	2369	1.29 (1.05, 1.60)	0.018	0.8 (0.58, 0.78)	<0.001
PT, seconds						0.38
10.4-13.4	963	1.38 (0.85, 2.23)	0.19	0.81 (0.64, 1.02)	0.078
< 10.4	41
> 13.4	2358	1.19 (0.99, 1.42)	0.063	0.61 (0.53, 0.71)	<0.001
APTT, seconds						0.44
22-35	2049	1.42 (1.07, 1.88)	0.016	0.69 (0.59, 0.81)	<0.001
< 22	63	—	—	—	—
> 35	1250	1.12 (0.91, 1.39)	0.28	0.61 (0.49, 0.74)	<0.001