Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice

Figure 2

Selection of 4-month-old SAMP8 mice for MCI. (a–c) The escape latency of 4-, 6-, and 8-month-old SARM1 and SAMP8 mice. (d) The escape latency of SAMP8 mice at 4-, 6-, and 8-month-old. (e) Target quadrant residence time, (f) platform crossing times and (g) swimming trajectories of SAMR1 and SAMP8 mice at 4-, 6-, and 8-month-old were measured in the MWM test. (h, i) Cerebral blood flow was measured using the Moor LDI2-HIR Laser Doppler. (j) The content of serum NEFL. Representative images of the hippocampus from (k) immunohistochemical staining of Aβ, (l) HE staining, and (m) Congo red staining. The magnification was 400x (scale bar = 50 μm). Data are expressed as mean ± SD and analyzed with one-way ANOVA; two-way ANOVA only was performed in the escape latency during the Morris water maze test.

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