Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice

Figure 3

JWKXS treatment ameliorated MCI. (a) Escape latency, (b) target quadrant residence time, (c) platform crossing times, and (d) swimming trajectories were measured through the MWM test. (e) Quantitative analysis of the content of Aβ in serum and hippocampus. Representative images of hippocampus showing the (g) HE staining, (h) Nissl staining, and (i) immunohistochemical examination of Aβ, and (f) Image-Pro Plus software was used to analyze the immunohistochemistry results. The original magnification was 40x (scale bar = 500 μm), medium-power magnification was 200x (scale bar = 100 μm), while the high magnification was 400x (scale bar = 50 μm). Data are expressed as mean ± SD and analyzed with one-way ANOVA; two-way ANOVA only was performed in the escape latency during the Morris water maze test.

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