Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice

Figure 7

JWKXS treatment inhibited Aβ1–42 induced BV2 microglial cells inflammation. (a–c) The contents of inflammatory cytokines TNF-α, IL-1β, and IL-6 in the cell culture supernatants. (d, e) The protein expression levels of TLR4, NF-κB P65, TNF-α, and IL-6. (f, g) The protein expressions of NLRP3, CASP1, cleaved CASP1/CASP1, IL-1β, and IL-18 in Aβ1–42-induced BV2 microglial cells. GAPDH and β-actin served as the internal control. Data are presented as mean ± SD.

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