Key Cell Types and Biomarkers in Heart Failure Identified through Analysis of Single-Cell and Bulk RNA Sequencing Data

Figure 4

Cell–cell communication signals participated by myeloid cells in HF: (a) bar plot illustrating significant signaling pathways in DCM, ICM, and normal groups. The overall flow of information in a signaling network is accomplished by aggregating all potential communication probabilities within the network; (b, c) comparative analysis of the significantly increased receptor–ligand pairs in ICM and DCM with myeloid cells as senders and receivers; (d) Venn diagrams of intersections between significantly co-upregulated genes in myeloid cells of DCM and ICM (Common_up) and receptor and ligands identified in Cellchat (Cellchat_LR); (e) circle plot for the inferred MIF-(CD74 + CXCR4) signaling network. The arrows indicate that the signal is transmitted from the sender to the receiver, while the thickness of the lines reflects the strength of their interaction.

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