A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling

<div>(a, b) The effect of LMT-28 at optimal concentration on JAK2-STAT3 and GP130 phosphorylation of osteoblasts at different times of stimulation (repeat three times). (c) The effect of dexamethasone and baricitinib on RANKL mRNA expression in osteoblasts. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling 

Figure 5 | A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling 