Mediators of Inflammation

New Developments in Cystic Fibrosis Airway Inflammation


Status
Published

Lead Editor

1Hospital for Sick Children RI, Toronto, Canada

2University of Toronto, Toronto, Canada

3University of Heidelberg, Heidelberg, Germany

4University Leiden, Leiden, Netherlands

5Weill Cornell Medical College, New York, USA


New Developments in Cystic Fibrosis Airway Inflammation

Description

The gene responsible for cystic fibrosis (CF) has been discovered 25 years ago. Since the identification of cystic fibrosis transmembrane conductance regulator (CFTR) as the gene responsible for causing CF, molecular and cell biological aspects of this ion channel have been systematically studied. Although the function of CFTR is now reasonably well-understood, how CFTR defects and other modifications result in chronic CF lung disease is not clearly understood.

Recurrent and chronic microbial infections and airway inflammation are the hallmarks of CF lung disease, and progressive lung disease remains the major cause of morbidity and mortality in patients with CF. Etiology and molecular mechanisms responsible for chronic infection and inflammation of the CF airways are not clearly understood. We are interested in compiling a comprehensive collection of articles that summarize well-established facts and highlight new developments in the topic of CF airway inflammation. This special collection would highlight molecular mechanisms responsible for chronic airway infection and inflammation, new experimental approaches, and potential therapeutic options for treating CF lung disease.

We invite investigators to contribute original research papers and review articles that will address the recent advances in CF airway inflammation.

Potential topics include, but are not limited to:

  • Introduction: the microenvironment of the CF lung:
    • Cells of the upper and lower airways
    • Infiltrating immune cells
    • The metabolites, lipid mediators, and cytokines
    • The microbiomes
    • How nutrition affects CF
    • Gender differences in CF
    • Non-CF bronchiectasis
  • The genetics and biochemistry of CF and their clinical relevance:
    • CFTR mutations
    • Genetic modifiers
    • CFTR protein modifications
  • New therapeutic approaches:
    • Preclinical animal models
    • Clinical studies
    • Stem cell-related screening approaches
    • Novel therapies
    • Personalized medicine strategies for treating CF lung disease

Note that Mediators of Inflammation has no page limits and no restriction on colour image publication and charges a fixed fee for articles. Papers will be published in the journal soon after their acceptance. The special issue will be assembled with a unique cover and an introductory editorial.


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 769425
  • - Editorial

New Developments in Cystic Fibrosis Airway Inflammation

Nades Palaniyar | Marcus A. Mall | ... | Hartmut Grasemann
  • Special Issue
  • - Volume 2015
  • - Article ID 529642
  • - Review Article

MicroRNA Dysregulation in Cystic Fibrosis

Paul J. McKiernan | Catherine M. Greene
  • Special Issue
  • - Volume 2015
  • - Article ID 545417
  • - Research Article

Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

Maria Galluzzo | Elisa Ciraolo | ... | Virginia De Rose
  • Special Issue
  • - Volume 2015
  • - Article ID 463016
  • - Review Article

The Contribution of the Airway Epithelial Cell to Host Defense

Frauke Stanke
  • Special Issue
  • - Volume 2015
  • - Article ID 547928
  • - Research Article

Epithelium-Specific Ets-Like Transcription Factor 1, ESE-1, Regulates ICAM-1 Expression in Cultured Lung Epithelial Cell Lines

Zhiqi Yu | Jun Xu | ... | Jim Hu
  • Special Issue
  • - Volume 2015
  • - Article ID 293053
  • - Review Article

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung

Matthew S. Twigg | Simon Brockbank | ... | Sinéad Weldon
  • Special Issue
  • - Volume 2015
  • - Article ID 626530
  • - Research Article

Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy

Ulrike Müller | Julia Hentschel | ... | Jochen G. Mainz
  • Special Issue
  • - Volume 2014
  • - Article ID 323526
  • - Research Article

Multitracer Stable Isotope Quantification of Arginase and Nitric Oxide Synthase Activity in a Mouse Model of Pseudomonas Lung Infection

Hartmut Grasemann | Thomas Jaecklin | ... | Felix Ratjen
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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