Mediators of Inflammation

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018


Status
Published

Lead Editor

1University of São Paulo, São Paulo, Brazil

2Universidade Estadual Paulista, São Paulo, Brazil

3University of Vienna, Vienna, Austria

4Loughborough University, Loughborough, UK


Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018

Description

Chronic nonresolving inflammation is a critical phenotype found in several highly incident metabolic diseases such as obesity, cancer, type 2 diabetes mellitus, and atherosclerosis. Despite major implication in disease, the mechanisms underlying the development and failure to resolve metabolic disease-associated chronic inflammation are still not completely elucidated. Several lines of evidence indicate the existence of a complex interrelationship between inflammatory processes and tissue function and metabolism. In this sense, exposure to high levels of some nutrients found upon overnutrition, among other situations, was demonstrated to modulate leukocyte function and induce inflammatory processes. Indeed, changes in the activity of the nutrient sensors mTOR and PPARs, for example, are associated with important alterations in inflammatory processes. Conversely, inflammation and inflammatory mediators are also associated with major changes in cell and tissue function and metabolism. For instance, chronic inflammation is associated with impairment of insulin’s ability to stimulate muscle glucose uptake and to inhibit adipocyte lipolysis. Therefore, a deep understanding of the intense cross-talking between metabolic organs (liver, adipose tissue, skeletal muscle, and gastrointestinal tract) and immune system is of major importance to the development of efficient strategies to treat metabolic diseases.

In this special issue, we invite investigators to contribute original research and review articles that address the complex interrelationships between immune system and metabolism. We are particularly interested in articles describing novel mechanisms of interaction between nutrients and metabolites, immune function and inflammation, and possible strategies to prevent or treat metabolic diseases.

Potential topics include but are not limited to the following:

  • Cell nutrient and energy sensors (G protein-coupled receptors, mTOR, PPARs, AMPK, etc.) as regulators of leukocyte function, immune responses, and inflammation
  • Exercise as anti-inflammatory therapy and immunometabolics mechanisms regulated by exercise
  • Microbiome and therapies associated with pre- and probiotics in metabolic diseases
  • Modulation of lipid, protein, and carbohydrate metabolism by inflammatory mediators
  • Metabolomics and lipidomics of cells and tissue upon inflammatory conditions

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 2340914
  • - Editorial

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018

José C. Rosa | Fabio S. Lira | ... | Nicolette C. Bishop
  • Special Issue
  • - Volume 2018
  • - Article ID 2037838
  • - Review Article

Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases

José E. Belizário | Joel Faintuch | Miguel Garay-Malpartida
  • Special Issue
  • - Volume 2018
  • - Article ID 5425346
  • - Research Article

Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

Kun-Chen Lin | Christopher Glenn Wallace | ... | Hon-Kan Yip
  • Special Issue
  • - Volume 2018
  • - Article ID 5906819
  • - Research Article

Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses

Duale Ahmed | Allison Jaworski | ... | Edana Cassol
  • Special Issue
  • - Volume 2018
  • - Article ID 8261432
  • - Review Article

Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

Alex S. Yamashita | Thiago Belchior | ... | William T. Festuccia
  • Special Issue
  • - Volume 2018
  • - Article ID 1312626
  • - Research Article

Folic Acid Improves the Inflammatory Response in LPS-Activated THP-1 Macrophages

Mirian Samblas | J. Alfredo Martínez | Fermín Milagro
  • Special Issue
  • - Volume 2018
  • - Article ID 4934592
  • - Research Article

Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

Yiyi Jin | Jianchang Qian | ... | Guang Liang
  • Special Issue
  • - Volume 2018
  • - Article ID 1419352
  • - Research Article

New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation

Anna Santarsiero | Pietro Leccese | ... | Vittoria Infantino
  • Special Issue
  • - Volume 2018
  • - Article ID 9186940
  • - Review Article

The Role of Galectins as Modulators of Metabolism and Inflammation

Monica Fengsrud Brinchmann | Deepti Manjari Patel | Martin Haugmo Iversen
  • Special Issue
  • - Volume 2018
  • - Article ID 7859601
  • - Research Article

The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway

Yao Wang | Hui Chen | ... | Zuo-Jiong Gong
Mediators of Inflammation
 Journal metrics
Acceptance rate41%
Submission to final decision77 days
Acceptance to publication36 days
CiteScore3.570
Impact Factor3.545
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