Mediators of Inflammation

Inflammatory and Fibrotic Mediators in Renal Diseases


Status
Published

1Institute for Biomedical Research (IRBLleida), Lleida, Spain

2Autonoma University, Madrid, Spain

3University Medical Center Utrecht, Utrecht, Netherlands


Inflammatory and Fibrotic Mediators in Renal Diseases

Description

Chronic kidney disease (CKD), independently of its etiology, is a major public health problem. This disease is characterized by a persistent inflammation, leading to fibrosis and loss of renal function. During renal inflammation, resident cells can produce a large array of inflammatory mediators, such as cytokines and adhesion molecules and also induce the activation of the complement system to contribute to the recruitment of leukocytes into the kidney. The activation of these responses occurs through a wide and complex axis of signalling pathways inducing the infiltration of inflammatory cells and the differentiation/proliferation of myofibroblasts. These processes contribute to the chronification of the inflammatory process and, ultimately, to fibrosis.

Nowadays, the therapeutic protocols applied for CKD treatment have limited effectiveness underscoring the importance of the development of new molecular diagnostic approaches and therapeutic targets to either prevent or delay the progression of the renal diseases. We invite the original research as well as review articles that will help to understand the inflammatory and profibrotic mechanisms that regulate key processes in the renal pathology and new therapeutic strategies for the treatment and prevention of CKD.

Potential topics include but are not limited to the following:

  • Immune response associated to Inflammation in renal pathology
  • Inflammatory and profibrotic regulators as potential therapeutic targets
  • Inflammation and fibrotic process and downstream signalling during the CKD and acute kidney disease
  • The tipping point between inflammation and fibrosis in CKD
  • In vitro and in vivo models to study the inflammatory and fibrotic mechanisms of Kidney diseases
  • Breakthrough advancements in the current understanding of the role of inflammation and fibrosis in renal diseases

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 7025251
  • - Editorial

Inflammatory and Fibrotic Mediators in Renal Diseases

Sandra Rayego-Mateos | Roel Goldschmeding | Marta Ruiz-Ortega
  • Special Issue
  • - Volume 2018
  • - Article ID 8739473
  • - Review Article

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

Sandra Rayego-Mateos | Raul Rodrigues-Diez | ... | Marta Ruiz-Ortega
  • Special Issue
  • - Volume 2018
  • - Article ID 5103672
  • - Research Article

IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney

Kritika Ramani | Roderick J. Tan | ... | Partha S. Biswas
  • Special Issue
  • - Volume 2018
  • - Article ID 3952526
  • - Research Article

sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction

Maëlle Plawecki | Marion Morena | ... | Jean-Paul Cristol
  • Special Issue
  • - Volume 2018
  • - Article ID 7659243
  • - Research Article

Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients

Agnieszka Żyłka | Paulina Dumnicka | ... | Marek Kuźniewski
  • Special Issue
  • - Volume 2018
  • - Article ID 6909035
  • - Research Article

Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice

Yao Xu | Yuqing Liu | ... | Wei Ding
  • Special Issue
  • - Volume 2018
  • - Article ID 5270657
  • - Research Article

Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy

Jie Hou | Manli Zhang | ... | Yanfang Jiang
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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