Mediators of Inflammation

Intracellular Eukaryotic Pathogens’ Virulence Attributes and Their Interplay with Host Immune Defenses


Status
Published

1University of Brasília, Brasília, Brazil

2Albert Einstein College of Medicine, New York, USA

3University of Goiás, Goiânia, Brazil


Intracellular Eukaryotic Pathogens’ Virulence Attributes and Their Interplay with Host Immune Defenses

Description

The incidence of life-threatening infections by intracellular eukaryotic pathogens has risen sharply as a result of modern medical care that may diminish immunity in patients and of immunosuppressive diseases. Thus, the clarification of these pathogens’ virulence attributes and host immune defense mechanisms is imperative.

Host-pathogen interactions are complex, dynamic, and multifactorial processes. In order to survive and proliferate within the host, eukaryotic pathogens must be able to sense different host microenvironment signals and regulate transcription and translation reprogramming, associated with metabolic adaptation, alterations in cellular morphology, and adjustments and remodeling of their surface envelope (cell wall/plasmatic membrane), among other processes. On the other hand, effective host responses require the ability of the host to recognize and respond to the pathogen employing several mechanisms to eradicate and/or control the pathogen through the activation of an efficient immune response.

In this special issue we invite scientists to contribute original research reporting novel and significant findings as well as review articles that will offer insights into host-pathogen interactions.

Potential topics include but are not limited to the following:

  • Phenotypic switching and its importance for virulence within the host
  • Transcriptomic and proteomic analyses of host-pathogen interactions
  • Virulence attributes regulating antimicrobial resistance
  • Intracellular pathogen subversion of innate immune recognition

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 1264974
  • - Editorial

Intracellular Eukaryotic Pathogens’ Virulence Attributes and Their Interplay with Host Immune Defenses

Anamélia Lorenzetti Bocca | Célia Maria de Almeida Soares | ... | Ildinete Silva-Pereira
  • Special Issue
  • - Volume 2017
  • - Article ID 7375818
  • - Research Article

The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection

Kristina Behnke | Ursula R. Sorg | ... | Klaus Pfeffer
  • Special Issue
  • - Volume 2017
  • - Article ID 8952878
  • - Research Article

Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata

Maria Helena Galdino Figueiredo-Carvalho | Lívia de Souza Ramos | ... | Rosely Maria Zancopé-Oliveira
  • Special Issue
  • - Volume 2017
  • - Article ID 9870679
  • - Review Article

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

Juliana Alves Parente-Rocha | Alexandre Melo Bailão | ... | Maristela Pereira
  • Special Issue
  • - Volume 2017
  • - Article ID 8491383
  • - Review Article

Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival

Gregory M. Gauthier
  • Special Issue
  • - Volume 2017
  • - Article ID 5313691
  • - Review Article

Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies

Emma Camacho | Gustavo A. Niño-Vega
Mediators of Inflammation
 Journal metrics
Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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