Mediators of Inflammation

Cardiovascular Involvement in Sepsis


Status
Published

1Universita degli Studi di Foggia, Foggia, Italy

2Sapienza University of Rome, Rome, Italy

3Centre Universitaire Romand de Médecine Légale (CURML), Lausanne, Switzerland

4University of Alberta, Edmonton, Canada


Cardiovascular Involvement in Sepsis

Description

Myocardial dysfunction is a common complication in patients with severe sepsis, and early recognition and aggressive supportive therapy are mandatory as mortality in patients with septic shock is still high. The pathophysiology of sepsis is a complex and dynamic process that originates from the host immune response to infection and varies according to the genetic predisposition, immune status, and comorbid conditions of the host, the type of pathogen, and the site and extent of infection. In this complex scenario, the phenomenon of myocardial depression is mediated by circulating depressant substances, including tumor necrosis factor alpha and various cytokines. In addition, myocardial depression in sepsis appears to be mediated in part through combinations of oxidative stress unbalance, mitochondrial damage, and activation of apoptotic pathways.

We invite original research and review articles focusing on interaction of cardiac inflammation, oxidative stress, and hypoxia in the setting of sepsis.

Potential topics include, but are not limited to:

  • Pathophysiology of myocardial depression in the setting of sepsis
  • Biomarkers of oxidative stress and inflammation in cardiac dysfunction in sepsis
  • Role of myocardial apoptosis in sepsis as a key step toward myocardial dysfunction
  • Role of cellular response as initiator/mediator of cardiac dysfunction in sepsis
  • Microcirculatory alterations in severe sepsis
  • Personalized medicine approach to heart failure in sepsis
  • Postmortem cardiac findings and their interpretation

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8584793
  • - Editorial

Cardiovascular Involvement in Sepsis

Emanuela Turillazzi | Vittorio Fineschi | ... | Consolato Sergi
  • Special Issue
  • - Volume 2016
  • - Article ID 3423450
  • - Review Article

Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations

M. Neri | I. Riezzo | ... | E. Turillazzi
  • Special Issue
  • - Volume 2016
  • - Article ID 4062829
  • - Review Article

A Pathophysiological Insight into Sepsis and Its Correlation with Postmortem Diagnosis

C. Pomara | I. Riezzo | ... | E. Turillazzi
  • Special Issue
  • - Volume 2016
  • - Article ID 9743198
  • - Research Article

Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy

Wei Hu | Pang-hu Zhou | ... | Xiao-bin Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 235742
  • - Research Article

Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing Coronary Angiography

Yan Zhang | Sha Li | ... | Jian-Jun Li
  • Special Issue
  • - Volume 2015
  • - Article ID 607364
  • - Research Article

Association of Metabolic Syndrome with the Adiponectin to Homeostasis Model Assessment of Insulin Resistance Ratio

Yu-Song Ding | Shu-Xia Guo | ... | Lie-Gang Liu
Mediators of Inflammation
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Acceptance rate36%
Submission to final decision53 days
Acceptance to publication29 days
CiteScore6.000
Impact Factor3.758
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