Mediators of Inflammation

Pharmacological and Non-Pharmacological Therapies Applied to Inflammatory Disorders


Publishing date
01 Sep 2021
Status
Closed
Submission deadline
16 Apr 2021

1University of Alfenas, Alfenas, Brazil

2Universidade Federal de Viçosa, Viçosa, Brazil

3Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico

4Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Brazil

5North Carolina State University, Raleigh, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Pharmacological and Non-Pharmacological Therapies Applied to Inflammatory Disorders

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Immunological homeostasis is achieved by strict control of the production and activation of proinflammatory and anti-inflammatory molecular and cellular effectors, which act synergistically to ensure the body's overall immunological balance. However, pathological conditions triggered by chemical, physical, and biological aggressions (i.e., pathogenic organisms) disrupt this immune balance. Thus, immune-mediated lesions develop in response to the upregulation of proinflammatory effectors and/or downregulation of counterregulatory anti-inflammatory mechanisms. In some cases, inflammatory disorders have self-limiting behaviour, and a well-adjusted immunological status is naturally re-established. However, pharmacological and non-pharmacological interventions are essential to control several acute and chronic inflammatory responses, limiting the development of immune-mediated injuries and stimulating tissue repair.

A wide range of natural and synthetic treatments are available for pharmacological management of diseases involving inflammation. In general, antibacterial, antiparasitic, antifungal, and antiviral agents are effective in controlling inflammation by eliminating the aetiological agents. However, several antimicrobial molecules and drugs also have direct proinflammatory and/or anti-inflammatory effects, controlling inflammation through multiple mechanisms of action. In addition to drug therapy, non-pharmacological approaches, based on light (low-level laser therapy), sound waves (ultrasound), radiation (radiotherapy), temperature (cryotherapy), and mechanical forces (vibration), are systematically used and have been found to be effective in treating several diseases associated with acute and chronic inflammation due to marked immunomodulatory effects. Currently, the applicability and effects of pharmacological and non-pharmacological therapies are better understood when administered alone. However, the combined effect of these approaches is still poorly understood, representing an interesting research challenge to be pursued. Thus, exploring potential additive or synergistic interactions between drugs, natural and synthetic molecules, and between these products and non-pharmacological interventions can broaden the perspective for treating diseases associated with inflammation.

This Special Issue aims at creating an interdisciplinary forum to discuss the inflammatory dynamics involved in injury and tissue repair processes, as well as the morphological, molecular, and functional basis of pharmacological and non-pharmacological immunomodulatory therapies applied to tissue repair. This Special Issue covers articles containing primary research results (in silico, in vitro, and in vivo) as well as studies based on secondary data, such as comprehensive and systematic review articles. Submitted articles must illustrate and stimulate the continuing effort to understand proinflammatory and anti-inflammatory molecules, and how drugs and non-pharmacological immunomodulatory interventions interact to establish the balance between tissue damage and repair.

Potential topics include but are not limited to the following:

  • Inflammatory mediators involved in tissue damage and repair
  • Proinflammatory and anti-inflammatory mechanisms of pharmacological and non-pharmacological interventions
  • The effect of pharmacological and non-pharmacological immunomodulatory therapeutics
  • Combined therapy based on pharmacological and non-pharmacological immunomodulatory agents
  • Drug repositioning for application in inflammatory disturbances
  • In silico, in vitro and in vivo methods

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9828995
  • - Research Article

Enhanced H3K4 Trimethylation in TNF-α Promoter Gene Locus with Cell Apoptosis in the Ventral-Medial Striatum following Opioid Withdrawal of Neonatal Rat Offspring from Morphine-Addicted Mothers

Pei-Ling Wu | Jau-Ling Suen | ... | San-Nan Yang
  • Special Issue
  • - Volume 2021
  • - Article ID 9933532
  • - Research Article

Vagal Nerve Stimulation-Modulation of the Anti-Inflammatory Response and Clinical Outcome in Psoriatic Arthritis or Ankylosing Spondylitis

C. Brock | S. E. Rasmussen | ... | M. Pfeiffer-Jensen
  • Special Issue
  • - Volume 2021
  • - Article ID 5596339
  • - Research Article

Basil Polysaccharide Reverses Development of Experimental Model of Sepsis-Induced Secondary Staphylococcus aureus Pneumonia

Xi Chen | Yue He | ... | Chuanjiang Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 5562340
  • - Research Article

Assessment of the Vanillin Anti-Inflammatory and Regenerative Potentials in Inflamed Primary Human Gingival Fibroblast

Erica Costantini | Bruna Sinjari | ... | Giovanna Murmura
  • Special Issue
  • - Volume 2021
  • - Article ID 5575059
  • - Research Article

Zataria multiflora and Pioglitazone Affect Systemic Inflammation and Oxidative Stress Induced by Inhaled Paraquat in Rats

Fatemeh Amin | Arghavan Memarzia | ... | Mohammad Hossein Boskabady
  • Special Issue
  • - Volume 2021
  • - Article ID 6680456
  • - Research Article

The Proresolving Lipid Mediator Maresin1 Alleviates Experimental Pancreatitis via Switching Macrophage Polarization

Yingying Lu | Guotao Lu | ... | Zhihui Tong
  • Special Issue
  • - Volume 2021
  • - Article ID 6699560
  • - Review Article

Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids

Seidu A. Richard
Mediators of Inflammation
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Acceptance rate36%
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Acceptance to publication29 days
CiteScore6.400
Impact Factor4.711
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